diff --git a/scripts/run_integration_tests_x86_64.sh b/scripts/run_integration_tests_x86_64.sh
index b6dc9ddfd..45c47c133 100755
--- a/scripts/run_integration_tests_x86_64.sh
+++ b/scripts/run_integration_tests_x86_64.sh
@@ -185,6 +185,9 @@ sudo chmod a+rwX /dev/hugepages
 # Update max locked memory to 'unlimited' to avoid issues with vDPA
 ulimit -l unlimited
 
+# Set number of open descriptors high enough for VFIO tests to run
+ulimit -n 4096
+
 export RUST_BACKTRACE=1
 time cargo test $test_features "common_parallel::$test_filter" -- ${test_binary_args[*]}
 RES=$?